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Obesity-related health complications, such as dyslipidemia, glucose intolerance, insulin resistance, and chronic inflammation, can manifest themselves through reductions in skeletal muscle quality (i.e. skeletal muscle mass and function). This decrease in quality is partially due to an atrophying of the skeletal muscle, as a result of an imbalance in the rates of protein synthesis and degradation . Complicating the situation, when obese individuals lose body mass as part of an intervention strategy, there is an accompanying reduction in muscle mass . A loss in skeletal muscle mass would be deleterious in this situation, given its vast metabolic role in glucose and fat metabolism.
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