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Scintigraphy

Iodine-123 metaiodobenzylguanidine (¹²³I-MIBG) myocardial scintigraphy has been accepted asone of the most useful methods for the diagnosis of Parkinson’s disease (PD). Moreover, the accumulated evidencehas indicated that the heart-to-mediastinum (H/M) ratio correlates with the disease severity of hypokinesia/bradykinesia and rigidity. The present report describes the wearing-off predictions obtained from MIBG in patientswith early-stage PD. Iodine-123 metaiodobenzylguanidine (¹²³I-MIBG) myocardial scintigraphy has been accepted as one of the most useful methods for the diagnosis of Parkinson’s disease (PD). Moreover, the accumulated evidencehas indicated that the heart-to-mediastinum (H/M) ratio correlates with the disease severity of hypokinesia/bradykinesia and rigidity. The present report describes the wearing-off predictions obtained from MIBG in patientswith early-stage PD.Subjects were screened from consecutive patients at TokushimaUniversity Hospital who met the criteria for diagnoses of PDaccording to the United Kingdom Parkinson’s Disease Brain Bank. The PD onset ages of all of the patients were between 45 and 70 years.Exclusion criteria were the following: (1) no scan of MIBGscintigraphy within 5 years after the onset of motor symptoms; (2) fastdecline in dopaminergic drugs effect within 5 years after onset. In ourstudy, we scanned of MIBG scintigraphy within 5 yearsafter the onset of motor symptoms in all PD patients, and nodifferences were found in the prevalence of tremor was observed between the groups with and without low uptake. Yoshimichi Miyazaki, MIBG Myocardial Scintigraphy can Predict the Occurrence of Wearing-offPhenomenon in Early-stage Parkinson’s Disease
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Last date updated on July, 2014

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