In lung cancer, non-small cell lung cancer (NSCLC) cells are often intrinsically resistant to certain anticancer drugs, whereas small cell lung cancer (SCLC) cells can acquire resistance with continued administration of the drug. Cancer cells are intrinsically resistant to anti-cancer agents because of genetic and epigenetic heterogeneity. These cells also acquire resistance to a wide variety of chemotherapeutic drugs through alteration in absorption, metabolism and excretion of a drug. Strategies also quite often initiate cancer cells to evade cell death by expressing mechanisms of resistance known as MDR that can result from changes that limit accumulation of drugs within cells by limiting uptake, enhancing efflux, or affecting membrane lipids.
Journal Article is sometimes called a Scientific Article, a Peer-Reviewed Article, or a Scholarly Research Article. Together, journal articles in a particular field are often referred to as The Literature.
Journal articles are most often Primary Research Articles. However, they can also be Review Articles. These types of articles have different aims and requirements. Sometimes, an article describes a new tool or method.
Because articles in scientific journals are specific, meticulously cited and peer-reviewed, journal databases are the best place to look for information on previous research on your species. Without a background in the field, journal articles may be hard to understand - however, you do not need to understand an entire article to be able to get valuable information from it.
Last date updated on September, 2014