Carcinogenesis is the process by which normal cells are converted to cancerous cell. This process results in changes in the cell at cellular, genetic and epigenetic level resulting in controlled growth of the cells and finally resulting in a mass of malignant cells or tissue. Carcinogenesis arises as a result of mutation in the DNA, the blue print of life. These mutations results in the production of non-functional protein and various other effects like affecting signalling mechanism and finally results in the production of malignant mass. In a due course of time, these malignant mass of cells gains the ability to invade to other organs, by a process termed metastasis. The cause of these kinds of mutation can be due to various reasons. Mutation of a proto-oncogene or a tumour suppressor gene can also result cancer. In general, human body has the capacity to repair these mutations DNA repair mechanisms. When these DNA repair mechanism are deficient then it results in non-functional protein. These mutations can occur due to the presence of free radicals. The incidence of cancer is increased in recent years due to the drastic change in the life style. This has resulted in increased of intake of carcinogenic substance and hence has increased the risk of cancer irrespective of age. A cancerous cell can be characterized by various characters right from its phenotype to genotype. A carcinogenesis journal comprises of those articles that depict various these conditions. It is a muti-displinary journal that comprises manuscripts in the areas of cancer biology, which also puts forth the various prevention methods.
Last date updated on June, 2014