Experimental pharmacology is the division of pharmacology with an added focus on the experimental study of chemicals that requires an intimate knowledge of the biological systems being affected or under treatment. With the knowledge in the streams of cell biology and biochemistry been increasing the field of experimental pharmacology has also changed substantially. Now it has become possible through molecular analysis of the receptors on the cell surface to design chemicals that act on specific cellular signaling or metabolic pathways by affecting the sites directly on the cell-surface receptors which modulates and mediates the cellular signaling pathways and thereby controls cellular functioning. A chemical from the pharmacological point-of-view has various properties like half-life of active pharmaceutical ingredient, volume of chemical distribution, desired or toxic effects on the body, etc. A medication is said to have a therapeutic index or therapeutic window which describes the ratio of desired effect to toxic effect. Development of medication is thereby a vital concern to medicine. The metabolic stability and the reactivity of a candidate drug compound have to be assessed for drug metabolism and toxicological studies. High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information.The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Last date updated on June, 2014