âDrug-induced toxicity is a big issue in the clinical practice. Most drugs may cause adverse drug reactions, in small portion of patients. Understanding the mechanism could help us to predict, prevent, and treat the drug-induced toxicity. Although lots of researches have been done in this field, unfortunately, very few mechanisms are known. In recent couple decades, different â-omicsâ are used to investigate the mechanism of drug-induced toxicity, for example, genomics and proteomics. These omics could provide us the information at gene and protein level, respectively. The newly emerging metabolomics has been employed, which could tell us what already happened at molecular level. The novel mechanism provides insight into the mechanism of liver injury associated with co-therapy. Mechanisms of drug induced toxicity are very complicated, because drug combination, species differences, and individual difference make them more complex. In the future, integration of different omics and animal models are beneficial to investigate the mechanism of drug induced toxicityâ Metabolomics reveals the novel mechanism of drug toxic, Feng Li.
Clinical toxicology articles deals with the various drug induced toxicology mechanisms, causes, toxic reactions of specific drugs as well how the drug toxicity affects humans and treatment modalities. These articles thus help the clinicians to further investigate the mechanism of toxicity and major drugs responsible for adverse reactions.
Last date updated on June, 2014