âDrug toxicology is considered to be non-preventable, recent developments suggest these ADRs can be avoided through individualization of drug therapies based on genetic information, an application known as pharmacogenetics/pharmacogenomics. Pharmacogenetics was introduced in the 1950s after some researchers noticed that some ADRs could be linked to genetically determined variations in enzyme activity Pharmacogenomics-Guided Approaches to Avoiding Adverse Drug Reactions Chen XW, Liu W, Zhou SF.
An important goal for the next decade is to advance the study of pharmaco genetics to a point where a significant amount of drugs are individualized for patients based on their genetic information. Mutant alleles at a single gene locus are best studied individual risk factors for ADRs. Awareness of inherited variations of drug responsiveness, which remain constant throughout life, can lead to possible dose adjustments on the basis of the patients genetic makeup and are also likely to prevent ADRs Pharmacogenomics-Guided Approaches to Avoiding Adverse Drug Reactions Chen XW, Liu W, Zhou SF.
Journal of Clinical toxicology is best journal in the field of clinical toxicology that deal with drug toxicity and adverse drug reactions. This bi-monthly journal releases novel cases with adverse drug reactions and original research articles dealing with drug metabolism and toxicity.
Last date updated on June, 2014