Toxicology Research Updates

Clinical analytical toxicology is one of the most essential parts in treatment of patients poisoned with drugs or toxic chemicals in hospitals. The Clinical toxicological cases data compilation of the last 12 years (F.Y.2000/01-2011/12) shows insecticides (Nuvan, Chlorpyrifos, Methylparathion, Cypermethrin, Mix (Chlopyrifos+Cypermethrin), Furadon, Endosulfan, etc.) are the most frequently used poison by patients. The second commonly used poisons are drugs (Benzodiazepines, Paracetamol, Proxivon and Opiates, Chlorpramazine, etc.). Rat poisons (Aluminum/Zinc phosphide) are used only by 4% of patients who were poisoned. Trends of Clinical Toxicology Cases in Nepal Tuladhar BS One of the major areas of toxicological advancements is in the field of developmental toxicology. “Translational toxicology must similarly strive to identify applicable therapeutics that can safely and effectively mitigate potential harm from exposures. Since human exposures to chemicals, physical agents and social factors are inevitable, the human fetus is subject to effects that can have lifelong consequences. In order to apply the translational concept to developmental toxicology, we are guided by the modest number of established and accepted obstetrical therapeutics used primarily for fetal benefit”. Translational Developmental Toxicology: Prospects for Protective Therapeutic Obstetrical and Neonatal Interventions Hughes C, Waters M, Obasanjo I, Allen D Yet another area where clinical toxicology has much relevance is in drug toxicology and adverse drug reactions. “Virtually, every drug is able to produce unwanted adverse effects which can be predictable from the drugs known pharmacology and are usually dose dependent with high morbidity rate or unpredictable on the basis of the drug pharmacology. The latter reactions are generally unrelated to dosage and though comparatively rare, but they often cause serious illness and death. Unpredictable Systemic Risks to Topical Drugs (Abraham G).

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Last date updated on April, 2024