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Amitriptyline

Amitriptyline inhibits the membrane pump mechanism responsible for uptake of noradrenaline and serotonin in adrenergic and serotonergic neurons. Pharmacologically, this action may potentiate or prolong neuronal activity, since reuptake of these biogenic amines is physiologically important in terminating its transmitting activity. This interference with the uptake of noradrenaline and/or serotonin is believed to underlie the antidepressant activity of amitriptyline.