Drug discovery is a time consuming and cost intensive process. It takes around 12-15 years and costs up to â¬800 million in order to bring a new drug in market. Most drugs exert their therapeutic effect by binding to and regulating the activity of a particular therapeutic target. Identification and validation of such targets is a first and important step in drug discovery. Currently therapeutic targets can be identified using both structural and sequential approaches. Selectivity and specificity are not only major challenges in drug design but also important factors for withdrawing drug molecules from the market. There are numerous proteins in the human body and it is practically impossible to ascertain whether these drug molecules bind with high affinity only to intended target proteins or also interact with other off-targets. Vs Nitish Kumar Mishra, Application of Computational Proteomics and Lipidomics in Drug Discovery.
Last date updated on July, 2014