Academic journals are periodicals in which researchers publish their findings, mostly the recent ones. Academic journals are typically peer-reviewed journals that publish theoretical discussions and articles that critically review already published work. Academic journals serve as an important forum for researchers and academicians from where they can access important information about recent developments in their field. These journals are the first choice for any in-depth examination of an issue related to science. Science as we know is scarcely imaginable without the academic journal. OMICS Group International Journals fall under the academic category as they strictly adhere to peer-review process and follow the format by publishing mostly the original work. OMICS International journals publish periodically and contain a series of articles in each published issue. OMICS Group International is successfully running 700+ peer-reviewed journals and organizing over 100 International Science Conferences annually with the support of 30, 000 editorial board members. OMICS Group International signed an agreement with more than 100 international societies to make health care information Open Access.
Notch signaling pathway is a conserved developmental pathway which is involved in cell fate determination at the stage of embryonic development and also plays important roles in tissue and organ development, hematopoiesis, vascular growth. Most of the cancer cell lines have shown significant level of up regulation of its activator proteins and down regulations of its suppressor proteins. The âgain or lossâ of functions of these Notch pathway associated proteins have clearly proved its correlation with cancer development, and hence can be used as a biomarker for cancer diagnosis. Various molecular biology experiments have also shown that inhibition of the activators of this pathway can drastically reduce the cancer progression in different stages , hence identification of drug targetable proteins and their small molecule inhibitors in the pathway to reduce various types of cancer development is always been an important field of research to the pharmacists and clinical biologists. Recent identification of GAMMA SECRETASE as a probable drug target in the pathway is found to reduce the Notch pathway activity by not allowing it to cleave the Notch receptor in the membrane.(Chowdhury S, Sarkar RR, Drug Targets and Biomarker Identification from Computational Study of Human Notch Signaling Pathway)
Last date updated on July, 2014