The development of the âidealâ drug delivery device, other issues are also worthy of mention. Antibiotic resistance among ocular pathogens, due to misuse and overuse of topical antibiotics in the eye, improper dosing regimen, and extended duration of therapy, is becoming increasingly prevalent.One of the key considerations is the ability for some microbes (such as fungi) to develop resistant spores. Upon exposure to an antimicrobial agent, the vulnerable microbes are killed but the spores can continue to remain dormant and unaffected. When the agent is removed, the spores become active and resume normal growth. The current approach to drug delivery using Contact Lenses in which drugs are continuously released, may lead to the development of resistant spores. Pulse drug delivery systems, although still in their infancy, have addressed some of the problems in regards to microbial resistance. By delivering the drug in multiple-timed doses, this method offers greater efficacy in killing microbes at doses almost half that of conventional therapies. This concept has not yet been adapted to Contact Lenses for drug delivery, and is worth considering for future development. (Chau-Minh Phan, Alex Hui, LakshmanSubbaraman and Lyndon Jones, Insights to Using Contact Lenses for Drug Delivery)
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Last date updated on September, 2020