A strain to be selected for fermentation process should satisfy the following criteria- it should be able to produce the desired product and produce the product at large scale, it should be a well-known organism, it should be able to grow faster, it should be safe to handle, it should grow in minimal to moderate growth media, it should have optimum growth temperature considerably above 400c, reduces the cooling costs and will be beneficial for isolation procedures at large scale fermentation processes, it should be genetically stable and simple to understand, it should be easier to manipulate it at genetic level, product recovery should be easy from the culture. Either pure cultures can be isolated from their natural habitats or can be acquired by order from culture collection centres. Natural habitat that we select for isolation of the desired strain should have a high biodiversity, should be unexplored and should encourage the dominance of desired microbial strain. Culture collection centre include ATCC, NCYC, JCM, NCIB etc. âStrain improvementâ has been a breakthrough of all commercial fermentation processes. This improvement process has been achieved through mutation or by genetic recombination and selection. This process enables the microbial strains to the overproduction of desired industrial products accordingly. Strain improvement through mutations include either chemicals or radiations as mutagen .
Scholarly peer review is the process of subjecting an author's scholarly work, research, or ideas to the scrutiny of others who are experts in the same field, before a paper describing this work is published in a journal. The work may be accepted, considered acceptable with revisions, or rejected. Peer review requires a community of experts in a given (narrowly defined) field, who are qualified and able to perform reasonably impartial review.
Last date updated on October, 2014