Aspirin (acetylsalicylic acid), is therapeutically used as an analgesic with fewer adverse reactions than salicylic acid. Through acetylation it was first generated as an antipyretic analgesic from of salicylic acid in the late 19th century. Worldwide aspirin has long been used as an ingredient in anti-inflammatory agents. It has much therapeutic action which includes antiinflammatory, antipyretic and analgesic effects, as well as antiplatelet and antirheumatic effects. Aspirin has been used as a prescription drug and nonprescription (over-the-counter) drug, and demand for the drug has steadily increased. Yet times over dosage of aspirin leads to poisonous cases. Toxicological analysis showed high concentrations of the active metabolite of aspirin, salicylic acid, in the blood and brain. Metabolic acidosis that is characteristic of salicylism increases the distribution of salicylic acid into the brain. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Last date updated on July, 2014