|Plasma hypercholesterolemia is well known major risk factor for the development of atherosclerosis with the earliest effects manifested by endothelial dysfunction. The mechanisms, however, of hypercholesterolemia-induced endothelial dysfunction are still not well understood.The dominant types of endothelial ion channels, inwardly-rectifying K+ channels (Kir) are suppressed by enriching the cells with cholesterol or by exposing them to acetylated and very-low density lipoproteins (acLDL and VLDL).
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record