|Traumatic brain injury (TBI) is a major source of death and severe disability worldwide. In the USA alone, this type of injury causes 290,000 hospital admissions, 51,000 deaths, and 80,000 permanently disabled survivors. Antiplatelet use in patients with head injury and intracranial hemorrhage (ICH) has been associated with increase in hematoma growth and worse outcomes compared with patients without preinjury antiplatelet use. Aspirin and clopidogrel are the most commonly prescribed antiplatelet drugs. There seems to be a prevailing thought that platelet transfusion in these patients can restore platelet function, and this can in turn lead to limited hematoma growth and thus improved outcomes.
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