âAutoimmune encephalomyelitis (EAE) is one of several animal models of demyelinating disease in the central nervous system (CNS). The main mechanism of EAE is an autoimmune T-cell-specific reaction to one of several myelin antigens present in the CNS. Several DMTs for MS (e.g., Glatiramer Acetate and Natalizumab), were developed from studies in EAE. However, the EAE model has a number of pitfalls in failing to predict the outcome of certain approaches in MS. After many years of intensive studies and clinical trials, no myelin protein inducing autoimmune reaction in only MS patients has been confirmed. In addition, the autoimmune theory cannot explain neurodegenerative processes documented in the CNS of MS patients at the very early stage of the diseaseâ Balashov KE., Multiple Sclerosis: New Hypotheses Are Needed.
The close relation of this disease with multiple sclerosis made this serve as a model for the studies on multiple sclerosis. The journal of multiple sclerosis also thus considers this topic as one of the relevant and most discussed issues in the journal articles and discussion forums.
Last date updated on July, 2014