âCognitive impairments were reported in descriptions of Multiple Sclerosis (MS) as early as Jean-Martin CHARCOTâs first descriptions by 1868. However, there were only very few systematic studies in this domain until the contribution from Stephen M. Rao, twenty years ago. Since the introduction of specific standardized tools, such as the BRB, clinicians have become aware of neuropsychological consequences of this disease and consequently, have been able to embark on prospective and comparative studies that tried to characterize cognitive defects in the various forms and stages of MS.
Progress so far, however, is modest and much remains to be done. Still lacking are robust markers allowing prediction of poor intellectual outcome, and indeed the evolution of cognitive impairment and motor or sensory disability appear to be fairly independent, except for the link regularly found between cognitive slowing and EDSS. An important issue is the frequent underestimation or minimization of the heterogeneity of neuropsychological impairment in MS patientsâ Ehrle et al., Yet a Lot to Consider Regarding Cognition in Multiple Sclerosis.
Journal of Multiple Sclerosis is a recently launched scholarly open access journal highlighting the major issues on multiple sclerosis including multiple sclerosis cognition, multiple sclerosis and rehabilitation, epidemiology and genetics of multiple sclerosis.
Last date updated on July, 2014