|Infection with intracellular parasites such as Mycobacterium tuberculosis induces Th1 immune response whereas intestinal parasites, mainly helminthes, elicit Th2 immune response.The high rate of chronic malnutrition, widespread poverty, overcrowding, and high sero-prevalence of HIV infection has created an environment which made TB a formidable threat in Ethiopia. Most patients with TB but without other illnesses absorb antimycobacterial drugs reliably. The degrees of malabsorption appear to differ across populations. Intestinal parasitic infections are among the most common infections in the world, being responsible for considerable morbidity and mortality. Intestinal helminthes are estimated to account for the infection of over 1,400 million people globally and are among the most important health problems in the world, particularly in the developing countries. Intestinal helmenthic infections, such as ascariasis, trichuriasis and hook worm infections are also prevalent in Ethiopia.