The process of storing the amplitude of anomalous optical band increased by about 5%, which may indicate arranging the molecules of the crystal and a decrease of the free energy system CLCD [DNA-Gd]. X-ray studies CLCD [DNA-Gd], conducted after 200 days of storage in the laboratory, and not revealed significant differences in the properties of the crystal. The presence of CLCD [DNA-Gd] rigid DNA molecules containing phosphate groups with which ions of rare-earth metals form soluble compounds (solubility constant ~10-12), makes getting stabilized, do not change over time of their material properties with an extended range of conditions it existence. These data suggest that the stability nanoparticles CLCD [DNA-Gd] does not change with storage conditions laboratory within 200 days.The experimental results showed that the inclusion of gadolinium ions in CLCD DNA nanoparticles significantly reduces its toxicity on macrophages. Obviously, these lanthanides is firmly retained within the nanoparticles and not washed medium. Nanoparticles derived CLCD [DNA-Gd], remain stability in biological tissues and can be used in medicine.Given the specific magnetic properties of gadolinium ions, a study of the magnetic susceptibility and control over nanoparticle magnetic field inside the system simulating tube of capillaries was done. In a quartz cell the size of 0.5Ã1Ã3 cm3 was poured 0.5 ml of a mixture containing nanoparticles, and the process of radical polymerization using 2-methyl-methacrylate. (Olga V Kondrashina,Ð Targeted Drug Delivery System of Gd3+ for Neutron Capture Therapy against Cancer is Metalorganic Magnetic Nanoparticles)
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Last date updated on July, 2014