alexa Nuclear Receptors |omicsgroup|single Cell Biology

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Nuclear Receptors

Nuclear receptors (NRs) are members of a large superfamily of evolutionarily related DNA-binding transcription factors that regulate programs involved in a broad spectrum of physiological phenomena Before the genes encoding these receptors were cloned, the first NR was identified biochemically in the 1960s by Jensen and Khan in 2004. NRs have become recognized as a superfamily of transcription factors, and the NR research field has undergone very rapid development and covers areas ranging from structural and functional analyses to the molecular mechanisms of transcription regulation. The other class of NRs are the so-called orphan receptors, for which regulatory ligands are still unknown or may not exist (“true orphans”) or for which candidates have only recently been identified (“adopted orphans”). Controversy still exists regarding the evolutionary origin of the NR family as to whether the ancestral receptor was ligand-dependent or this feature evolved independently. Open Access journals are the major source of knowledge for young and aspiring generations who are keen in pursuing their careers in science. This system provides easy access to networks of scientific journals. Authors who contribute their scholarly works to Open Access journals gain remarkable reputation as the research scholars explore these works extensively. This process assures considerable impact factor for the journal and good reputation to the authors that add value to their Academic Performance Index (API) Score. Open access journal articles are essentially peer-reviewed and available for access through the directory of Open Access journals. OMICS Group International supports this system and provides access to 700+ peer-reviewed journals with no restrictions and thus promotes the Open Access movement with a view to promote scientific advancements.
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Last date updated on June, 2014

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