alexa A Comparative Study of the Effect of Gabapentin, Topiramate, Levetiracetam and Zonisamide for Neuropathic Pain Induced by Anticancer Drug (Vincristine) in Rats


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Research Article

A Comparative Study of the Effect of Gabapentin, Topiramate, Levetiracetam and Zonisamide for Neuropathic Pain Induced by Anticancer Drug (Vincristine) in Rats

 
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Abstract

Background: Neuropathic pain syndrome is a frequently occurring, disabling disease. Many anticancer drugs which are used to treat solid tumors cause neuropathic pain as their dose limiting side effect. Current treatment options are still relatively poor. Objective: The present study was designed to compare the effect of gabapentin, topiramate, levetiracetam and zonisamidefor treatment of neuropathic pain induced by anticancer drug(vincristine) in albinorats using thermal method. Materials and Methods: Neuropathic pain was induced by injecting vincristine (100μg/kg) intraperitoneally daily for 14 days in rats. Behavioural testing for thermal hyperalgesia was assessed 24 hours after each injection by the hot-plat method. After 14 days rats were divided into five groups of six animals each. Group I was treated with distilled water as control group, group II was treated with oral gabapentin (60 mg/kg), group III received oral topiramate (40 mg/kg), group IV was treated with oral levetiracetam (120 mg/kg) and group V received zonisamide (50 mg/kg).The antihyperalgesic effect of drugs was assessed by the hot-plate method 24 hours after each administration. Statistical analysis was done by two way analysis of variance (ANOVA) followed by post hoc test. Results: Gabapentin, topiramate and zonisamide treated groups showed asignificant(P < 0.0001) increase hot-plate latency as compared to control group. Levetiracetam treated group however, did not show a significant increase in hot-plate latency. Conclusion: In vincristine induced neuropathic pain gabapentin, topiramate and zonisamide appearto be promising drugs although they act by different mechanisms

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