alexa A perspective on Systemic lupus erythematosus (SLE)
ISSN: 2319-9865

Research & Reviews: Journal of Medical and Health Sciences
Open Access

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Review Article

A perspective on Systemic lupus erythematosus (SLE)

Puja1*, Ankita1, Mamatha M2

1Department of Bioinformatics, SRM University, Chennai, Tamil Nadu, India

2Department of Pharmacology, JNTU University, Hyderabad, Telangana, India

Corresponding Author:
Puja
Department of Bioinformatics
SRM University
Chennai, Tamil Nadu, India
Tel: +917032398719
E-mail: [email protected]

Received: 18/01/2015; Accepted: 20/02/2015; Published: 28/02/2015

 

Abstract

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease, which is autoimmune disorder. It affect multiple organs like skin, joints, kidneys, brain, and other organs. Although liver dysfunction is not considered the main organ pathology or prognostic factor in patients with Systemic Lupus Erythematosus (SLE), it is not uncommon during the course of SLE. Liver complications in patients with SLE may be caused by lupus hepatitis (SLE-related hepatitis); autoimmune liver diseases, such as Autoimmune Hepatitis (AIH) and Primary Biliary Cirrhosis (PBC); viral hepatitis; and drug-induced liver injury. Here, liver complications in patients with SLE are reviewed with a predilection for females, with a female-to male ratio of between 4.3 and 13.6, and a mean age at diagnosis of 34.3 years. Most are young women of childbearing age who suffer from such symptoms as intense fatigue and exhaustion, joint pains, thinking and memory problems, and skin rashes. In young adult women the peak incidence of about 5 in 100 000 per year.

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