alexa A Validated Spectrophotometric Method for Determination
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

A Validated Spectrophotometric Method for Determination of Paliperidone Palmitate in Bulk Drug and its Pharmaceutical Dosage Form

Rakshit Kanubhai Trivedi12*, Ravikumar Jupudiand1, Mukesh C Patel2, Dipika R Trivedi2, and Hitesh A Jogia1

1Analytical Research and Development, Integrated Product Development, Dr.Reddy’s Laboratories Ltd., Bachupally, Hyderabad-500 072, India.

2PS Science and HD Patel Arts College, SV Campus, Kadi-382 715, Gujarat, India.

Corresponding Author:
Rakshit Kanubhai Trivedi
Analytical Research and Development
Integrated Product Development
Dr.Reddy’s Laboratories Ltd.
Bachupally, Hyderabad-500 072, India.

Received date: 09/05/2013; Revised date: 16/05/2013; Accepted date: 02/07/2013



The present research describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for determination of paliperidone palmitate in bulk and extended release injectable suspension formulation. The Paliperidone palmitate obtained spectrum was determined at 278 nm. The linearity was obtained in the concentration range of 15.6-50 μg/ml for Paliperidone palmitate. Interference due to placebo was not observed at 278 nm. The recovery and precision was well within the ICH (International conference on Harmonization) define criteria. The method was found to be simple and sensitive for the Paliperidone palmitate determination in injectable suspension dosage form. The results of analysis have been validated statistically and by recovery studies.


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