alexa Ameliorative Effect of Hibiscus rosa sinensis on Pheny
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

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Research Article

Ameliorative Effect of Hibiscus rosa sinensis on Phenylhydrazine Induced Haematotoxicity

Anil Kumar Meena1, Devendra Patidar2 and R. K. Singh1*
  1. Technical Assistant, Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow
  2. Research Trainee, Department of Pharmacology, Manipal college of Pharmaceutical Sciences, Manipal
  3. Corresponding author- Senior Principal Scientist, Dr. R. K. Singh, CSIR-Central Drug Research Institute, Lucknow
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Abstract

This research work was focused on the haemoprotective activity of methanolic extract of Hibiscus rosa sinensis L. (HRS) flowers against phenylhydrazine induced haematotoxicity in Charles foster rats. Haemoprotective activity of methanolic extract of HRS flowers were estimated by using haematological parameter of Charles foster rats and it was evaluated with the help of MS9 fully automated haematology analyzer. The experimental activities for the methanolic extract of HRS exhibited statistically significant (p<0.005) haemoprotective activity against phenylhydrazine induced haematotoxicity in Charles foster rats. In conclusion, these observations provide evidence and possible mechanism of action for the haemoprotective activity of methanolic extract of HRS flowers. This activity of extract may be due to high phenolic and flavonoid contents.

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