ANTIDIABETIC ACTIVITY OF CINNAMOMUM MACROCARPUM HOOK.F.LEAVES ON ALLOXAN- INDUCED DIABETIC SWISS ALBINO MICE
The effect of ethanolic extract of Cinnamomummacrocarpum (CM) leaves on the functions of hyperglycemia, protein and serum marker enzymes were evaluated in Alloxan induced diabetic male Swiss Albino mice. After 15 days of administration of CM extract at an oral dose of 100 mg/kg body weight, significant increase in the levels of blood glucose in group II and decrease in the blood glucose level in group III, IV and V were observed. A decrease in the activities of serum protein, HDL and triglycerides in group II diabetic mice and these levels were increased in CM treated group III and IV. The marker enzymes SGPT, SGOT and ALP levels were significantly increased in group II animals and decreased in Alloxan treated groups and compared to normal. The groups treated with CM extracts showed significant decrease in the serum marker enzymes. The antidiabetic effect of CM extract was compared with the standard antidiabetic drug, glibenclamide.