Anti-Inflammatory Activity of Methanol Extract of the Whole Plant of Psychotria octosulcata. W. A. Talbot
In the present study, the anti-inflammatory effect of the methanol extract of the whole plant of Psychotria octosulcata was investigated. The methanolic extract of Psychotria octosulcata was ingested orally (p.o.) in the form of suspension in 0.5% Tween 80 in three different doses, (100,200 and 400 mg/kg body weight). The acute anti-inflammatory effect of Psychotria octosulcata was tested in carrageenan-induced paw oedema and chronic anti-inflammatory effect of Psychotria octosulcata was tested in cotton pellet granuloma pouch method in wistar albino rats and compared with the standard, diclofenac (40 mg/kg body weight). The results showed that Psychotria octosulcata has significant reduction (p≤0.01) in inflammation i.e. 67.94% (200 mg/kg body weight) in paw edema method and 72.61% (200 mg/kg body weight) in cotton pellet method as compared to the standard drug, diclofenac which was 69.23% and 74.85 respectively. These results indicate that the extracts could possess anti-inflammatory property. Both of the methods and the changes in the activities could be suggested as contributory effects to the use of Psychotria octosulcata in the management of inflammatory conditions.