alexa Anti-Oxidative Effects of Pyrogollol Lipid Derivatives on the Oxidation of Unilamellar Vesicles and Rat Blood Plasma
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Research Article

Anti-Oxidative Effects of Pyrogollol Lipid Derivatives on the Oxidation of Unilamellar Vesicles and Rat Blood Plasma

Jae-Hak Moon Jong Hoon Jeong*, Jeong-Yong Cho, Hang Yeon Jeong and Hyoung Jae Lee

Department of Food Science and Technology, and Functional Food Research Center, Chonnam National University, Gwangju 500-757, Republic of Korea

Corresponding Author:
Jae-Hak Moon
Department of Food Science and Technology, and Functional Food Research Center
Chonnam National University
Gwangju 500-757, Republic of Korea
Tel: +82625302141
Fax: +82625302149
E-mail: [email protected]

Received date: 21/03/2015; Accepted date: 08/07/2015; Published date: 14/07/2015

 

Abstract

Amphipathic pyrogallol lipid derivatives (PD) containing different carbon atomic length alkyl chains, including –H, –C5H11, –C10H21, –C15H31, and –C20H41 in the C-4 position of the benzene ring were synthesized. 4-Decylpyrogallol displayed contact hypersensitivity, but other compounds did not induce an allergic reaction when rat ears were sensitized with the compounds daily for 10 days. PDs containing more than five carbon atoms in the alkyl chain showed high lipophilicity in n-octanol/ water partition experiments and high rate of incorporation to liposome membranes. In addition, PDs showed higher radical-scavenging activity on 1,1-diphenyl-2-picrylhydrazyl than α-tocopherol and 3-pentylcatechol. PDs efficiently inhibited lipid peroxidation of egg yolk phosphatidyl choline large unilamellar vesicle liposomes induced by lipid- and aqueous-soluble radical generators. Moreover, PDs attenuated the formation of cholesteryl ester hydroperoxides in rat blood plasma induced by copper ions. These results suggest that non-allergenic PDs may act as potent antioxidants against the oxidative damage of cellular and subcellular membranes.

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