alexa Anti-Platelet Activities of Polyozellin In Vitro and In
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Anti-Platelet Activities of Polyozellin In Vitro and In Vivo

Eun-Ju Yang1#, Sae-Kwang Ku2# and Jong-Sup Bae1*

1College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701 Republic of Korea

2Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 712- 715, South Korea

#First two authors contributed equally to this work.

*Corresponding Author:
Jong-Sup Bae
College of Pharmacy
Research Institute of Pharmaceutical Sciences
Kyungpook National University 80 Daehak-ro
Buk-gu, Daegu 702-701, Republic of Korea
Tel: +82-53-950-8570
Fax: +82-53-950-8557
E-mail: [email protected]

Received: 07/11/2015 Accepted: 22/11/2015 Published: 30/11/2015

 

Abstract

Purpose: Thrombosis and thromboembolic occlusions of blood vessels are a major complication in various peripheral vascular diseases. The agents for the inhibition of platelet function are recognized as key tools in the treatment of atherothrombosis. Therefore, it became a mainstay medication for a wide range of vascular diseases. Polyozellin (POZ), a major constituent of an edible mushroom Polyozellus multiplex, was reported to have anti-oxidant, anti-angiogenesis, anti-cancer, and anti-inflammatory effects. However, anti-platelet effect of POZ has not been investigated yet. Methods: In our study, the anti-platelet activities of POZ were measured by thrombin- or collagen-induced platelet aggregation in vitro, adenosine diphosphate (ADP)-induced platelet aggregation in vivo, and the thrombus formation in vivo. Results: POZ effectively inhibited the platelet aggregation not only in vitro using freshly isolated human platelets, but also in vivo thrombin or collagen-induced platelet aggregation. In accordance with the anti-platelet activities in vitro, POZ enhanced anti-thrombotic effect in vivo pulmonary embolism model and arterial thrombosis model. Conclusion: These results indicate that POZ possesses anti-platelet activities and might be useful for developing the drug candidates or functional foods for treatment of cardiovascular diseases without side effects.

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