Aromatic-Aromatic Interactions in Biological System: Structure Activity Relationships
- *Corresponding Author:
- Rajagopal Appavu
Molecular Biophysics Unit
Indian Institute of Sciences-Bangalore
Received date: 29/01/2016 Accepted date: 22/02/2016 Published date: 26/02/2016
While, intramolecular hydrogen bonds have attracted the greatest attention in studies of peptide conformations, the recognition that several other weakly polar interactions may be important determinants of folded structure has been growing. Burley and Petsko provided a comprehensive overview of the importance of weakly polar interactions, in shaping protein structures. The interactions between aromatic rings, which are spatially approximate, have attracted special attention. A survey of the proximal aromatic residue pairs in proteins, allowed Burley and Petsko to suggest that, “phenyl ring centroids are separated by a preferential distance of between 4.5 and 7 Å, and dihedral angles approximately 90° are most common”.