alexa Cerebral Microhemorrhages on Susceptibility Weighted Im
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Research Article

Cerebral Microhemorrhages on Susceptibility Weighted Imaging After Aortic Dissection

Brian Mac Grory1, Ajay Malhotra2, Teddy S Youn3and Matthew Schrag4*

1Department of Neurology, Yale University and Yale New Haven Hospital, New Haven, Connecticut, USA

2Department of Radiology, Yale University and Yale New Haven Hospital, New Haven, Connecticut, USA

3Department of Neurology, University of Florida School of Medicine, Gainesville, Florida, USA

4Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA

*Corresponding Author:
Matthew Schrag
Department of Vascular Neurology
Vanderbilt University Medical Center
Medical Research Building III
465 21st Avenue S, Suite 6160 (Office 6158C)
Nashville, TN 37232, USA
Tel: 615 936- 0060
E-mail: [email protected]

Received date: May 11, 2017; Accepted date: June 02, 2017; Published date: June 09, 2017

Citation: Grory BM, Malhotra A, Youn TS, Schrag M (2017) Cerebral Microhemorrhages on Susceptibility Weighted Imaging After Aortic Dissection. J Alzheimers Dis Parkinsonism 7:334. doi:10.4172/2161-0460.1000334

Copyright: © 2017 Grory BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Cerebral microhemorrhages (CMHs) are detected on susceptibility weighted (SWI) and gradient recalled echo T2* (GRE-T2*) magnetic resonance imaging (MRI) and are useful biomarkers of microvascular diseases of the brain. Here we describe the characteristics and distribution of cerebral microhemorrhages in a series of subjects with aortic dissection, compared with an age- and sex-matched series of patient with severe, chronic hypertension. CMHs were discovered in 75% of subjects with aortic dissection with a median of 8 per subject and an average diameter of 2.6 mm. CMHs were primarily located within the frontal lobes, parietal lobes and deep white matter tracts in a pattern suggestive of a watershed distribution. The pattern of CMHs after aortic dissection was different from that related to severe hypertension, which may suggest a different mechanism. We propose that injury to distal arterioles from cholesterol micro emboli may account for the pattern of CMH observed after aortic dissection. Aortic dissection is an important mimicker of the neuroimaging findings of cerebral amyloid angiopathy and severe hypertension.

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