Review Article
Clotrimazole as a Cancer Drug:A Short Review
Kadavakollu S, Stailey C, Kunapareddy CS and White S*Department of Natural Sciences, Western New Mexico University, Silver City, NM, 88061, USA
- *Corresponding Author:
- Shawn White
1000 W. College Ave, Western New Mexico University
Silver City, NM88061, USA
Tel: 575-538-6564
Fax: 575-538-6228
E-mail: [email protected]
Received date: September 17, 2014; Accepted date: October 20, 2014; Published date: October 22, 2014
Citation: Kadavakollu S, Stailey C, Kunapareddy CS, White S (2014) Clotrimazole as a Cancer Drug: A Short Review. Med chem 4:722-724. doi:10.4172/2161-0444.1000219
Copyright: © 2014 Kadavakollu S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Although clotrimazole was first used against fungal infections, a body of research was later developed indicating that this drug has anticancer properties as well. The mechanism of action is based on the inhibition of mitochondrialbound glycolytic enzymes and calmodulin, which starves cancer cells of energy. Clotrimazole and its derivatives have been shown to decrease rates of cancer cell proliferation, induce G1 phase arrest, and promote pro-apoptotic factors, which lead to cell death.
