alexa Dronedarone-induced Pulmonary Toxicity - A Case Report and Literature Review

Research & Reviews: Journal of Hospital and Clinical Pharmacy
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Case Report

Dronedarone-induced Pulmonary Toxicity - A Case Report and Literature Review

Young R. Lee1*, Erica J. Wilson2 and Preston L. Pate3

1Adult Medicine Division, Texas Tech University Health Sciences Center, School of Pharmacy, USA

2Medical Center Health System, Odessa, TX, USA

3Hendrick Medical Center, Abilene, TX, USA

*Corresponding Author:
Young R. Lee
Assistant Professor of Pharmacy Practice
Texas Tech University Health Sciences Center School of Pharmacy
1718 Pine Street, Abilene, TX, USA
Fax: 3256763824
Tel: 3256960449
E-mail: [email protected]

Received date: 16/03/2016; Accepted date: 06/04/2016; Published date: 20/04/2016



Dronedarone is an amiodarone analog often used to treat atrial fibrillation as it is typically thought to have a more favorable safety profile than amiodarone including less major organ toxicities. Although rare, there are published case reports and the presented case that describe the association of pulmonary toxicity and dronedarone which should prompt clinicians to heed the warnings of the Federal Drug Administration and monitor for side effects of dyspnea in patients on this therapy. The authors present a case of a 69-year-old male with atrial fibrillation, congestive heart failure, and chronic obstructive pulmonary disease with worsening dyspnea that was admitted for an elective bronchoscopy. His current medications included dronedarone for atrial fibrillation. The timeline of drug initiation, rapid patient improvement upon drug discontinuation and steroid therapy, and unique radiological imaging are consistent with dronedarone induced pulmonary toxicity.


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