alexa EFFECT OF α-TOCOPHEROL PRETREATMENT ON EPIDIDYMAL


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Research Article

EFFECT OF α-TOCOPHEROL PRETREATMENT ON EPIDIDYMAL WEIGHT, SPERM COUNT & SPERM MORPHOLOGY ON CADMIUM INDUCED TESTICULAR DAMAGE IN MALE ALBINO RATS

Rekha D Kini1,Yogesh Tripathi2, C V Raghuveer3, Sheila R Pai1, Nayanatara AK1
  1. Departments of Physiology, Center for Basic Sciences, Kasturba Medical College, Bejai, Manipal university, Mangalore-575004, Karnataka, India
  2. Dept .of Physiology, Santhosh Medical college, New Delhi
  3. Dept.of Pathology, Srinivas Medical College, Mangalore, Karnataka
Received: 01 June 2012 Accepted: 07 June 2012
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Abstract

Cadmium is one of environmental pollutantsarising from electroplating, fertilizers, pigment and plastic manufactures. Clinical and animalstudies indicate that abnormalities of spermatogenesis result from exposure to this toxic metal. The purpose of present study was to evaluate the protective role of α-tocopherol on cadmium chloride induced testicular damage. Material & Methods: Adult male wistar rats (n=6/group) were divided in four groups, normal control(0.9% saline treated), Vitamin E treated(100mg/kg bw) orally for 30 days, cadmium chloride treated(0.5mg/kg bw) & vitamin E for 30 days+ cadmium treated. Animals were sacrificed 15 days after cadmium administration or saline administration.Epididymal weight & sperm count ,sperm morphology were estimated in each group.Results: Exposure of rats to cadmium chloride showed a decrease in the epididymal weight (P<0.001) and, sperm count(P<0.001), increase in the incidence of abnormal sperms(P<0.001). Pre-treatment with α-tocopherol showed a significant increase in the epididymal weight (P<0.001) and, sperm count(P<0.001), decrease in the incidence of abnormal sperms(P<0.001) compared to on cadmium treated rats. The present study show that cadmium at the dose of 1mg/ kg b w administered is responsible for testicular damage and that α-tocopherol protects the testis from cadmium induced damage

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