alexa Effect of Amitriptyline on the Pharmacokinetics of Diva


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Amitriptyline on the Pharmacokinetics of Divalproex Sodium in Normal Rabbits

 
To read the full article Peer-reviewed Article PDF image

Abstract

The present study was aimed at investigating the effect of Amitriptyline on the pharmacokinetic of Divalproex in rabbits. Divalproex and Amitriptyline are used for long duration and indicated for CNS disorder like depressive disorder, personality disorder and migraine, respectively. The pharmacokinetic parameters of Divalproex sodium (6 mg/kg, p.o.) was compared with concomitant administration of Divalproex sodium (6 mg/kg, p.o.) and Amitriptyline (10 mg/kg, p.o.). The blood samples were collected at different time interval of 30 min, 1st, 2nd, 4th, 8th, and 16th hour. Divalproex dissociates to release valproate and valproic acid in the gastrointestinal tract. The concentration of Valproic acid (VPA) in serum was then estimated by HPLC coupled with Mass Spectroscpoy (LC-MS/MS). The serum concentration of VPA was significantly increased after Amitriptyline treatment for 7 days. Pharmacokietic parameters like AUC, AUMC, T1/2 and Cmax of VPA showed significant change after Amitriptyline treatment in healthy albino rabbits. Divalproex and Amitriptyline both are metabolized by the same enzyme; CYP2C9. Amitriptyline inhibits UDP-glucuronosyltransferases (UTG), where Divalproex is substrate of UTG metabolism. Both reasons may lead to increase in serum VPA concentration. Change in the time and frequency of administration of Divalproex sodium is suggested when both drugs are administered concomitantly. Therapeutic drug monitoring should be performed as combination may lead to remarkable increase in valproic acid serum level.

Keywords

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords