alexa Effect of Ginkgo biloba on Renal Ischemia-Reperfusion Induced Oxidant Stress in Rats
e-ISSN: 2322-0139 p-ISSN: 2322-0120

Research & Reviews: Journal of Pharmacology and Toxicological Studies
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Research Article

Effect of Ginkgo biloba on Renal Ischemia-Reperfusion Induced Oxidant Stress in Rats

Amit Singh1*, Surendra Pratap Mishra2, and Abha Mishra3

1Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, India.

2Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, India.

3School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, India.

*Corresponding Author:
Amit Singh
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, India
Mobile: +91 9452567899

Received date: 15 December 2012 Accepted date: 30 December 2013

 

Abstract

Ginkgo biloba extract was evaluated for prophylactic value against renal ischemia-reperfusion induced oxidant stress in rat subjected to transient unilateral renal artery ligation. Oral Ginkgo biloba treatment (2mg/kg) was administered by different schedule before experimental induction of ischemia-reperfusion injury. Malondialdehyde has been taken as indicator for free radical damage produced by ischemia-reperfusion injury. Three hour pretreatment by the drug has most prominent inhibitory effect on consequent tissue and plasma malondialdehyde level of lipid peroxidation. Further, the relative inhibition of malondialdehyde level in tissue and plasma allow to infer drug effect on generation, but not the clearance of malondialdehyde. No significant difference of outcome from 1, 2 and 3 days treatment indicate no cumulation and thus safety in that respect. Ginkgo biloba treatment appears both effective and safe for prophylaxis of reperfusion injury following ischemia catastrophies.

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