Effect of Vitamin E and C plus Reduced Glutathione in Treatment of Diabetic Nephropathy
Diabetes has describes, a group of metabolic diseases due to high blood sugar. Their uncontrolled lead to prolonged hyperglycemia resulting in long-term microvascular/macrovascular complications; and nephropathy is one of them. Objective: To evaluate the combine effect of antioxidant vitamins E and C plus reduced glutathione in diabetic nephropathy. Method: A randomized, open controlled clinical trial was conducted on 216 diabetic nephropathy patients who have had diabetes for at least 5 years. Result: 216 patients were selected and divided in to four groups such as positive control, vitamin, reduced glutathione and combination of vitamin E and C plus reduced glutathione. After 4 months supplementation of vitamin E and C plus reduced glutathione, it was found that the, vitamins and reduced glutathione treated groups shows significant (p<0.009 and p<0.002) decreased microalbuminuria levels from 33.2±2 to 30.5±2 and 31.4±2 to 30.1±1 as compared to control group. Interestingly, treatment of glutathione plus vitamins exhibited significant decreased (p<0.001) values from 33.3±2 to 27.2±2. Similarly, its effect on total protein shows significant difference (p<0.01 and p<0.05) decline in level from 8±0.4 to 7.6±0.3; 7.8±0.3 to 7.5±0.3 in vitamin and glutathione plus vitamin combination as compared to control and glutathione group alone. Conclusion: Diabetes is a chronic illness that requires a combine effect of treatment regimen for better glycemic control and to prevent its complications. So it has been suggested that initiating therapy with combination of antioxidants vitamin E and C plus reduced glutathione significantly lowers urinary albumin excretion rate and total protein in diabetic nephropathy.