EFFECTS OF MATERNAL LEAD ACETATE EXPOSURE DURING LACTATION ON POSTNATAL DEVELOPMENT OF OVARIES IN OFFSPRING OF SWISS ALBINO MICE
|Durgesh Nandini Sharma* and Lata Bhattacharya
Endocrinology and Physiology Unit, School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, M.P., India
|Corresponding Author: Durgesh Nandini Sharma, Tel: +919424045828, E-mail: [email protected]|
|Received: 25 February 2014 Accepted: 27 March 2014|
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The course of human development from conception to adulthood is extremely complex. The developing organism is particularly vulnerable to toxic insult because of rapid cell division and differentiation and severely affected during gestation and lactation. The aim of the present study was to evaluate lead toxicity on the female reproductive system during neonatal period. A total of 30 female mice randomly divided into two equal groups; control and treatment group. During experimental period, lactating female mice was given lead acetate (0.5ml/Day) from day 1 to day 21 of lactation. At 7, 14 and 21 days after birth, the ovaries weights and diameters of different developing follicles were measured. Following tissue processing, 5 μm sections were stained with haematoxylin eosin and evaluated with quantitative techniques. Ovarian parameters in different groups were compared by one-way ANOVA. The results indicated that exposure of lead caused histological alteration in developing ovaries of mice and significantly (P< 0.05) decreased Ovaries weights and diameters of different developing ovarian follicles. Studies conducted on females revealed that lead suppresses the development of various follicles during fetal and neonatal life. It appears that lead interferes during specific events of ovarian developmental stages, which may create higher sensitivity for dysfunction in reproductive system during adulthood. The present investigation evaluates the relative influences of prenatal and postnatal exposure of lead acetate on growth and ovarian histology in female offspring during postnatal development.