alexa Estimation of Non micronized Piroxicam in SEDDS Formula

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Research Article

Estimation of Non micronized Piroxicam in SEDDS Formulation by HPLC Method

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The different assay methods for the determination of Piroxicam in the pharmaceutical preparation have been reviewed. The determination of recoveries of Piroxicam has been described by HPLC method. The aim of the present study was to develop and validate analytical method for determination of non micronized Piroxicam in SEEDS formulation in hard gelatin capsules by High Performance liquid chromatography (HPLC) method. It is therefore necessary to study the behavior of non micronized Piroxicam when it is incorporated in SEDDS formulation. The HPLC method was developed using chromatopack, peerless basic C18, 250x4.6mm, 5μm analytical column. The mobile phase comprising of acetonitrile : potassium dihydrogen ortho phosphate buffer [pH-3.0] in the ratio (40:60) v/v. The flow rate was maintained at 1.0ml/min and elute was monitored by using U.V detector at 230nm.The retention time of Piroxicam was about 12 minutes. The method was validated for its specificity, accuracy, precision, and linearity, limit of detection(LOD), limit of quantification(LOQ), robustness and stability parameters. The linear regression analysis data for the calibration plots shows a good linear relationship over the concentration range of 5-150 mg/mL. The method showed good recoveries (98.0 – 99.8%) and has been applied to formulation without interference of excipients in the formulation. The result of method was reproducible and within official limits. The HPLC method has been proved more authentic as it can be used for the quantitative and entrapment efficient to determine non micronized Piroxicam in SEDDS formulation in hard gelatin capsules.


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