Evaluation of Antidepressant Activity of Simvastatin in Albino Mice
OBJECTIVE: Evaluation of acute antidepressant property of Simvastatin in albino mice. BACKGROUND: Cholesterol is an important determinant of the structure and function of cell membranes, and plays an integral role in many neural functions that contribute to mood state. Cholesterol may have a role in the pathophysiology of depression. Lowering cholesterol levels with statins reduces risks for cardiovascular events, and statins exert neuroprotective properties by increasing BDNF level. METHOD: Total of 84 mice was taken, 42 were taken for Tail suspension test (TST) and 42 for Forced swimming test (FST). Each model had 7 groups of 6 mice in each group. Group 1 is taken as a control, group 2 standard Fluoxetine [SSRI](5mg/kg), group 3 standard Amitriptyline [TCA](10mg/kg) , group 4 and 5 test drug( simvastatin) in doses of 5mg/kg and 10mg/kg, group 6 combination of simvastatin(5mg/kg) and sub effective dose of fluoxetine(2.5mg/kg), group 7 combination of simvastatin(5mg/kg) and sub effective dose of amitriptyline(5mg/kg). RESULTS: Simvastatin presents significant antidepressant effect at all doses, indicated by reduction in immobility time in both FST and TST. There was significant reduction in immobility period when simvastatin was combined with sub effective dose of fluoxetine[SSRI] and sub effective dose of amitriptylin[TCA]. CONCLUSION: Simvastatin shows significant antidepressant effect in mice. It potentiates the action of sub effective dose of Fluoxetine and Amitriptyline when given in combination, raising the possibility that simvastatin can be used to facilitate the action of other antidepressants or can themselves can be used as antidepressants in humans.