EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT FROM LEAVES OF SOLANUM AMERICANUM
|B. Satheesh Kumar1*, J. Sathyanarayana2, M. Krishna Reddy2 and M.S.K. Prasad1
|Corresponding Author: B. Satheesh Kumar, E-mail: [email protected], Phone: +91 9951104576|
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There is a growing interest in herbal remedies because of their effectiveness, minimal side effects in clinical experiments and relatively low cost. Solanum americanum is an herbaceous flowering plant, reported in Indian medicinal literature with beneficial effects as antiinflammatory, anti-spasmodic, anti-vasodilator and anti-jaundice etc. The present study was aimed to investigating the possible hepato protective activity of S. americanum in order to evaluate the claim by traditional herbalists in India. The hepatotoxicity produced in rats by administration of CCL4 in paraffin oil (1:9 v/v) at a dose of 1 ml/Kg. b.wt. for 10 days, was found to be reduced by simultaneous oral administration of aqueous extract of S. americanum leaves (200, 400, 600 mg/ Kg. b.wt.) for 10 days, with evidence of decreased levels of serum aspartate amino transferase, alanine amino transferase, alkaline phosphatase and bilirubin. The results were compared with the hepatoprotective effect of the standard drug Silymarin. The results of this study indicated that the aqueous extract of S. americanum leaves could afford a significant protection against CCL4 induced hepatotoxicity in rats and confirm the claim on this plant as a potential hepatoprotective agent in the traditional medicine.