EVALUATION OF THE ANTI-PROLIFERATIVE AND IMMUOMODULATORY EFFECT OF SALLYL CYSTEINE ON PULMONARY FIBROSIS INDUCED-RATS
|Amal Attia El-Morsy Ibrahim1,2 and Mona Ramadan Al-Shathly2
|Corresponding Author: Amal A.E. Email: Ibrahim [email protected]|
|Received: 24th Feb-2014 Accepted: 19th March-2014|
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The present study aimed to evaluate the immunomodulatory effect of s-ally cysteine (SAC) on pulmonary fibrosis in CCl4-induced rats. The animals divided into: group (I) served as control and its rats were administered olive oil. Rats of group (II) received SAC. Animals of group (III) were injected with CCl4 to induce pulmonary fibrosis. Rats of group (IV) treated with CCl4+SAC. Lung tissues from CCl4-injected rats revealed thickened alveoli septa, lymphatic nodules, marked increase in collagen fibres. Increase in the expression of α-smooth muscle actin (α-SMA) and glutathione S-transferase (GST). Proliferating cell nuclear antigen (PCNA) showed increase in the apoptotic activity reached 28.9%. CCl4 injection caused augmentation in INF-γ and serum cytokines. SAC administration may became a novel potential treatment for pulmonary fibrosis due to its anti-proliferative activity recorded 11.82%, which is possible mediated by induction of apoptosis, beside its inhibitory effect on GST, cytokines production, which thereby modulates collagen synthesis, and attenuated the pulmonary fibrosis.