Formulation and Evaluation of Herbal Antidandruff Shampoo Containing Garlic Loaded Solid Lipid Nanoparticles
In the present study, herbal antidandruff shampoo containing garlic loaded solid lipid nanoparticles were formulated by using garlic as a antifungal agent. The ALL -SLNs were formulated by hot homogenization method and evaluated by using different parameter. The zeta potential, particle size and polydispesity index ,SEM and drug release were performed for ALL-SLNs. Result showed of ALL- SLNs containing Tween 80 (1ml) and soy lecithin (10ml) formulations showed the excellent zeta potential, particle size entrapment efficiency, SEM study revealed irregular surfaces with pores. The in vitro release upto 90% and %EE was found to be 30-50% .Then herbal antidandruff shampoo were formulated by using mixing process and evaluated. Result of antidandruff shampoo containing different concentration of CMC and EDTA were excellent appearance, viscosity, pH, foam ability, spreadibility and in vitro release. The pH and viscosity of herbal antidandruff shampoo were found to be 3.7-7.2 and 1010cps -1700 cps. The spreadibility was found to be by different method and result was found to be 46.4% and 53.1%. Foamability was found to be 157ml. The in vitro drug release profile was 79.26 to 80.4%. Thus it is more effective for the treatment of dandruff on scalp and hair with no side effect.