alexa Formulation and Evaluation of Lidocaine Lozenges
ISSN ONLINE(2319-8753)PRINT(2347-6710)

International Journal of Innovative Research in Science, Engineering and Technology
Open Access

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Research Article

Formulation and Evaluation of Lidocaine Lozenges

 
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Abstract

Inspite of several dosage forms available in the market for effective localized action, the lozenges finds a special importance as they are the best dosage forms for formulating large dose medicaments. The anatomy of mouth and cheek favours easy absorption of drug, reducing the systemic absorption thus ensuring a better patient compliance especially for paediatrics and geriatrics. Lidocaine mechanism of action suites this type of formulation and easily absorbed in oral cavity. Preformulation studies are primarily done to investigate the physicochemical properties of drug and to establish its compatibility with other excipients. Lidocaine (DRUG) was mixed with all excipients, used in the formulation in different ratios and subjected to FTIR Physical observation. It was observed that there is no colour change and drug degradation as the peaks remained the same in the FTIR graphs. Lidocaine hard candy lozenges were prepared by heat fusion method using sugar as a base. The usage of corn syrup in the formulation made the lozenges transparent and smooth, which helped in improving the elegancy of formulation. The controlled release of medicament from Lozenges was achieved by using polymers like methyl cellulose, locust bean gum, HPMC K4M and xanthan gum. The prepared lozenges were subjected to physico-chemical as well as in vitro drug release study. Among all the formulations of hard candy lozenges FL8 showed the in vitro release of 98.7% at the end of 25 minutes.

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