alexa Formulation and Evaluation of Tramadol HCL Pulsatile Dr

Journal of Formulation Science & Bioavailability
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Research Article

Formulation and Evaluation of Tramadol HCL Pulsatile Drug Delivery by Using Press Coating Technique

Sriharitha B1*, Preethi J2 and Rishpa K3

1Depertment of Pharmaceutics, ASN Pharmacy College, Acharya Nagarjuna University, India

2Department of Chemistry, Acharya Nagarjuna University, India

3Department of Industrial Pharmacy, St. Peter’s College of Pharmacy, Kakatiya University, India

*Corresponding Author:
Sriharitha B
Department of Pharmaceutics
ASN Pharmacy College
Acharya Nagarjuna University
Tenali, India
Tel: +91-9492029026
Email: [email protected]

Received Date: May 02, 2017; Accepted Date: May 19, 2017; Published Date: May 23, 2017

Citation: Sriharitha B, Preethi J, Rishpa K (2017) Formulation and Evaluation of Tramadol HCL Pulsatile Drug Delivery by Using Press Coating Technique. J Formul Sci Bioavailab 1: 110.

Copyright: © 2017 Sriharitha B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The main aim of the present work is to develop and evaluate pulsatile press coated tablets which release total amount of drug at early morning. Here core tablet (180 mg) containing Tramadol hydrochloride 50 mg with excipients crospovidone, sodium starch glycolate and croscarmellose sodium was prepared by direct compression. The core tablet was then coated by coating material composed of combination of polymers hydroxy propyl methyl cellulose (HPMC-K100M) and ethyl cellulose (EC) by press coating technique. Prepared Press Coated tablet was evaluated for all physical tests. In-vitro dissolution test was carried out in 0.1 N HCl for first two hrs and 6.8 pH phosphate buffer for remaining period. From that formulations PCF3 containing polymer ratio of (3:1) i.e. HPMC:EC was selected as optimized formulation as it retarded drug release in stomach and shows a drug release with significant lag time. Initially compatibility study was carried out by FTIR showing that all the excipients and polymers were compatible with drug. Keywords: Pulsatile drug delivery; Press coated tabl

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