alexa Generic Vs. Branded: A Comparative Dissolution Study of Some Commercially Available Levofloxacin Hemihydrate Film Coated Tablets and their Pharmacoeconomic Evaluations


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Research Article

Generic Vs. Branded: A Comparative Dissolution Study of Some Commercially Available Levofloxacin Hemihydrate Film Coated Tablets and their Pharmacoeconomic Evaluations

 
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Abstract

The main objective of the present study was to conduct a comparative study of various branded dosage forms and generic dosage form todetermine whether all the formulations were equivalent. Five different brands of marketed product of Levofloxacin Hemihydrate (250mg) (A, B, C, D, E) and one product of generic formulation (F) were purchased and were analysed. The results showed that all the branded and generic product of Levofloxacin Hemihydrate film coated tablets met the pharmacopoeial specifications. Further, all the tablets passed the hardness, thickness, length, diameter, depth, weight variation tests, disintegration time and dissolution study as per pharmacopoeia. Disintegration time for generic product was found to be 15.1 ± 1.153 minutes which was higher than all the branded products. The dissolution study data of all the formulations passed the test as per the pharmacopoeia. Further, it was observed from the dissolution data that of the five branded products; three of these released the drug in 15 minutes and the remaining two in 20 minutes while the generic product released the drug in 30 minutes. Hence it may be conclude that all the branded products and the generic form of Levofloxacin Hemihydrate film coated tablets (250mg) were found to be equal, hence generic product should be prescribed by health care professionals as the cost of generic product is comparatively less to an extent of 30-50 % of the branded products which may reduce the cost of medication to the patients.

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