alexa Inulin for Cancer Therapy: Present and Perspectives


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Review Article

Inulin for Cancer Therapy: Present and Perspectives

G. Giammona*1,2, N. Mauro1, C. Scialabba1

1Laboratory of Biocompatible Polymers, Department of Science and Technology Biological, Chemical and Pharmaceutical (STEBICEF), University of Palermo, Italy.

2Mediterranean Center for Human Advanced Biotechnologies (Med-Chab), VialedelleScienze Ed.18, 90128 Palermo, Italy.

Corresponding Author:
G. Giammona
Laboratory of Biocompatible Polymers
Department of Science and Technology Biological
Chemical and Pharmaceutical (STEBICEF), University of Palermo
Via Archirafi, 3290123 Palermo, Italy
E-mail: [email protected]

Received date: 31 December 2015; Received in revised form date: 14 January 2016; Accepted date: 17 January 2016

 

Abstract

Inulin is an extremely adaptable polysaccharides consisting ofglucopyranose end-capped (β-1,2) fructose repeating units and, as it is, can be classified as an inherently multifunctional polymeric scaffold. It may be further functionalized employing mild conditions to give rise desired biological and physicochemical properties exploitable for targeted anticancer applications (e.g., active targeting toward specific cytotypes, self-assembling behavior, selective cytoxicity and hyperthermia features). In this review, the main chemical features and the inulin derivatives applications in the field of targeted anticancer therapy is reported and discussed

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