alexa METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATON OF CILOSTAZOL AND TELMISARTAN
e-ISSN: 2320-0812 p-ISSN: 2347-2340

Research & Reviews: Journal of Pharmaceutical Analysis
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Research Article

METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATON OF CILOSTAZOL AND TELMISARTAN

Dharmendra Damor, Karan Mittal, Bhoomi Patel and Rajashree Mashru*

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, G. H. Patel Building, Donor’s Plaza, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara-390 002, Gujarat, India.

*Corresponding Author:
Rajashree Mashru
Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System
Pharmacy Department, The Maharaja Sayajirao, University of Baroda, Fatehgunj
Vadodara-390 002, Gujarat, India
E-mail: [email protected]

Received date: 23/05/2015; Accepted date: 25/08/2015; Published date: 01/09/2015

 

Abstract

Three rapid, sensitive and specific UV-Visible methods were developed and validated for the estimation of Cilostazol and Telmisartan in synthetic mixture. All method was validated according to ICH guideline in terms of linearity, accuracy, precision, and specificity, limit of detection and limit of quantification. The first method is simultaneous equation method. Method I is based on simultaneous equation. Cilostazol and Telmisartan show absorbance maximum at 258 and 296 nm respectively, so absorbance was measured at the same wavelength for estimation of Cilostazol and Telmisartan. Method II is based on determination of Q-value. Absorbance is measured at 237.5 nm (Iso absorptive point) and 258 nm (λ max of Cilostazol). Method III is dual wavelength method, in which two were selected for each drug in a way so that the difference in absorbance is zero for another drug. Both drugs obey the Beer Lambert’s law in the concentration range of 1-40 μg/ml for Cilostazol and 1-25 μg/ml for Telmisartan.

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