Study of Lactic Acidosis Induced by ART Drugs
The aim of the study was to compare the serum lactate levels and the incidence of lactic acidosis in either gender of HIV seropositive individuals on ART with stavudine or zidovudine combination drugs and to evaluate the association between duration of Antiretroviral therapy and changes in the level of lactic acid. This is a hospital based prospective study. After obtaining informed consent, blood samples were collected from the patients and lactic acid levels were measured using lactate assay kit and the association between the duration of antiretroviral therapy and changes in lactate level were evaluated. The collected data were analyzed using the Statistical software namely SAS 9.0, SPSS 15.0, Stata 8.0, MedCalc 9.0.1 and Systat 11.0. Among 70 patients included in the study, 34 (48.6%) were males and 36 (51.4%) were females. In this study shows that, incidence of lactic acidosis is higher in female gender. Of the total patients 46 (65.7%) received d4T regimen and 24 (34.3%) received AZT regimen. A higher S.Lactate level was found to be in patients receiving stavudine than in zidovudine therapy. In this study, S.Lactate level was found to be high in the group receiving ART since 24 months followed by 18-24 months, 12-18 months,6-12 months, and a minimum level in 6 months. This study suggests the increased risk of lactic acidosis with longer duration of NRTIs therapy. This study confirms that, a higher incidence of lactic acidosis in female gender and the risk of this complication increases with long term use of NRTIs.