The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in MiceShuang Guan1,2, Sitong Ma2, Linli Xu2, Tong Wang2, Mengrou Ren2, Xuming Deng1, Jing Lu1,2*
- *Corresponding Author:
- Jing Lu
Laboratory of Nutrition and Function Food
Jilin University, Changchun, Jilin130062
E-mail: [email protected]
Received: 22 July 2015 Accepted: 28 July 2015 Published: 05 August 2015
This study aimed to clarify the toxicity effects of 3-monochloro-1,2- propanediol(+) (3-MCPD(+)) on activated T cell in mice. The toxicity effects of 3-MCPD (+) on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that 3-MCPD(+) markedly inhibited ConA-induced T lymphocytes proliferation, Th1/Th2 cytokines production, activated Ca2+/ CaM/I-κB-NF-κB and Ca2+/CaM/CaN/NFAT signal transduction pathways in vitro. Furthermore, administration of 3-MCPD significantly inhibited T cell-mediated DTH response in vivo. These observations indicated that 3-MCPD (+) exhibited suppressive effects on activated mouse T cell in vitro and in vivo.