alexa The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in Mice
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in Mice

Shuang Guan1,2, Sitong Ma2, Linli Xu2, Tong Wang2, Mengrou Ren2, Xuming Deng1, Jing Lu1,2*

1Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People’s Republic of China

2Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, People’s Republic of China

*Corresponding Author:
Jing Lu
Laboratory of Nutrition and Function Food
Jilin University, Changchun, Jilin130062
Tel: +8643187836161
Fax: +8643187836160
E-mail: [email protected]

Received: 22 July 2015 Accepted: 28 July 2015 Published: 05 August 2015

 

Abstract

This study aimed to clarify the toxicity effects of 3-monochloro-1,2- propanediol(+) (3-MCPD(+)) on activated T cell in mice. The toxicity effects of 3-MCPD (+) on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that 3-MCPD(+) markedly inhibited ConA-induced T lymphocytes proliferation, Th1/Th2 cytokines production, activated Ca2+/ CaM/I-κB-NF-κB and Ca2+/CaM/CaN/NFAT signal transduction pathways in vitro. Furthermore, administration of 3-MCPD significantly inhibited T cell-mediated DTH response in vivo. These observations indicated that 3-MCPD (+) exhibited suppressive effects on activated mouse T cell in vitro and in vivo.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords