alexa The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in Mice
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

The Toxicity of 3-Monochloro-1,2-Propanediol (+) on Activated T Cell in Mice

Shuang Guan1,2, Sitong Ma2, Linli Xu2, Tong Wang2, Mengrou Ren2, Xuming Deng1, Jing Lu1,2*

1Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin 130062, People’s Republic of China

2Laboratory of Nutrition and Function Food, Jilin University, Changchun, Jilin 130062, People’s Republic of China

*Corresponding Author:
Jing Lu
Laboratory of Nutrition and Function Food
Jilin University, Changchun, Jilin130062
Tel: +8643187836161
Fax: +8643187836160
E-mail: [email protected]

Received: 22 July 2015 Accepted: 28 July 2015 Published: 05 August 2015



This study aimed to clarify the toxicity effects of 3-monochloro-1,2- propanediol(+) (3-MCPD(+)) on activated T cell in mice. The toxicity effects of 3-MCPD (+) on murine T lymphocyte responses were evaluated in vitro and in vivo. The data showed that 3-MCPD(+) markedly inhibited ConA-induced T lymphocytes proliferation, Th1/Th2 cytokines production, activated Ca2+/ CaM/I-κB-NF-κB and Ca2+/CaM/CaN/NFAT signal transduction pathways in vitro. Furthermore, administration of 3-MCPD significantly inhibited T cell-mediated DTH response in vivo. These observations indicated that 3-MCPD (+) exhibited suppressive effects on activated mouse T cell in vitro and in vivo.


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